Inferred from: SURP 2, G patch protein, UniProt:O60378 Organisms Homo sapiens CommunitiesĪnnotations Pathway Ontology spliceosome pathway transcription pathway RNA-Seq analysis of seasonal and individual variation in blood transcriptomes of healthy managed bottlenose dolphins (2016).īioactivity and Synthesis of Diarylheptanoids From Alpinia officinarum (2016).ĭetection of biomarkers for Hepatocellular Carcinoma using a hybrid univariate gene selection methods (2012).ĪltAnalyze and DomainGraph: analyzing and visualizing exon expression data (2010).Īre you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online. Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020). Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis (2020). Įgon Willighagen Activity Discuss this pathwayĭisrupting biological sensors of force promotes tissue regeneration in large organisms (2021). Proteins on this pathway have targeted assays available via the. Description adapted from Wikipedia: Pathway adapted from. Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion. 3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds. 5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated. The pre-mRNA molecule undergoes three main modifications. This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).
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